& Randall, C
Wallerian degeneration is executed by an NMN-SARM1-dependent late Ca(2+) influx but only modestly influenced by mitochondria
Clinically, observational data suggest a 19% lower glaucoma incidence in GLP-1RA-treated diabetic patients than those on other antidiabetic regimens (Figure 1, this review comprehensively analyzes the mechanistic basis of GLP-1RAs in ocular diseases, synthesizes emerging clinical and preclinical evidence, and underscores their potential to redefine therapeutic strategies for vision-threatening disorders through multi-targeted disease modification
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Key protocol components, including eligibility criteria, treatment strategies, assignment procedures, follow-up, outcome definitions, causal contrast, identifying assumptions and the data analysis plan, were translated into operational definitions using validated claims-based algorithms and observational analogs of key study design choices
